Image Credit: iakovenko/123rf.com
Researchers at Northwestern University have made significant strides in developing a potential new treatment for vitiligo, an autoimmune disorder that affects millions globally. This condition occurs when the immune system mistakenly attacks melanocytes, the cells responsible for producing skin pigment, leading to patchy skin discoloration. While existing treatments like steroid creams can have undesirable side effects and inconsistent results, this new approach leverages beneficial gut bacteria to address the underlying issues of the disease.
The study focuses on the role of probiotics, specifically a genetically modified strain of Bacillus subtilis, which is commonly found in the gut and soil. Previous observations indicated that individuals with vitiligo often exhibit an imbalance in skin bacteria, with harmful microbes dominating and protective probiotic bacteria in short supply. By enhancing Bacillus subtilis to increase its production of exopolysaccharides (EPS)—compounds known to mitigate immune responses—researchers tested its efficacy in mice predisposed to vitiligo.
Over an 18-week period, the mice received weekly EPS injections, resulting in a remarkable 74 percent reduction in pigment loss compared to untreated control mice. Additionally, the treated mice exhibited a significant decrease in cytotoxic T cells, which are responsible for attacking melanocytes, alongside an increase in regulatory T cells that help protect these vital cells from immune attacks.
Although further research is necessary, this study opens the door to potentially transforming vitiligo treatment. Scientists are now investigating how to adapt this probiotic-based therapy for human use, considering options such as topical ointments or food additives, rather than relying solely on injections. As millions of individuals seek more effective treatments for vitiligo, this groundbreaking research represents a promising advancement in the quest for solutions to this challenging condition.
Check out the original article here: Source link
