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Scientists at the Indian Institute of Science (IISc) have developed an innovative solution for tooth sensitivity that involves the use of nanorobots. Known as CalBots, these tiny robots are designed to create permanent protective plugs in the exposed tubules of sensitive teeth, potentially offering a long-term remedy for this common dental issue.
Tooth sensitivity occurs when the enamel on a tooth wears down, exposing the microscopic channels, or tubules, that lead directly to the nerve endings. This exposure can result in sharp pain triggered by cold, hot, or sweet substances. Traditional treatments, such as desensitizing toothpaste, provide only temporary relief by calming nerve response or partially blocking these tubules.
The new CalBots, measuring just 400 nanometers wide, are made from magnetic iron oxide and a specialized calcium-silicate-based bioceramic. This bioceramic mimics the structure of tooth enamel, allowing the robots to form a lasting seal within the sensitive tubules. The application process involves guiding the CalBots into the tooth’s surface using an external magnetic field. Within 20 minutes, they successfully form stable plugs that can reach depths of 300 to 500 micrometers, acting as a barrier to irritants and preventing pain signals from reaching the nerves.
Initial tests have shown promising results. The research team started by applying the CalBots to extracted human teeth, where they proved effective at plugging exposed tubules. Further studies involved mice with induced tooth sensitivity. After treatment with CalBots, the mice were able to consume cold water, indicating a significant reduction in sensitivity.
The IISc research team is now in the process of commercializing this technology through a spinoff company, Theranautilus, with plans to bring the CalBot treatment to dental clinics in the near future. The findings of this study were published in the peer-reviewed journal Advanced Science, highlighting its potential impact on dental health.
As researchers continue to explore the capabilities of nanorobotics in healthcare, CalBots may soon provide a breakthrough solution for individuals suffering from tooth sensitivity, moving beyond temporary fixes to offer a more permanent cure.
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